Publikationen

    Association of uterine activity and maternal volatile anesthetic exposure during open fetal surgery for spina bifida: a retrospective analysis

    S. Tra a, N. Ochsenbein-Kölble b, e, P. Stein c, M. Meuli d, e, U. Moehrlen d, e, L. Mazzone d, e, F. Kraehenmann b, e, R. Zimmermann b, e, P. Biro a, e

    Recent warnings postulate a possible damaging effect of volatile anesthetics on the fetus. In our archive of fetal surgeries, we found wide variation in dosing of volatile anesthetics during spina bifida surgeries. We hypothesized that there was an association between volatile anesthetic exposure and uterine activity.

    PMID: 33780714 DOI: 10.1016/j.ijoa.2021.102974

    Journal: International Journal of Obstetric Anesthesia (Volume 46, May 2021, 102974) - published online: March 10, 2021

    DateEnglish: 01/05/2021

    a Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland

    b Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

    c Institute of Anesthesiology, Emergency Medical Service, Perioperative Medicine, Pain Therapy, Cantonal Hospital Winterthur, Switzerland

    d Department of Surgery, University Childrens’ Hospital Zurich, Zurich, Switzerland

    e The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland

    Long-term Outcomes of Children After Fetal Surgery for Spina Bifida-Toward Sustainability

    Martin Meuli 1, 2, 3, Ueli Moehrlen 1, 2, 3

    No abstract available

    PMID: 33555285 DOI: 10.1001/jamapediatrics.2020.5687

    Journal: JAMA Pediatrics 2021;175(4):e205687 - published online: February 8, 2021

    DateEnglish: 01/04/2021

    1 Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

    2 The Zurich Center for Fetal Diagnosis and Therapy, University of Zurich, Zurich, Switzerland.

    3 Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.

    Fetal surgery for spina bifida in Zurich: results from 150 cases

    Ueli Moehrlen 1, 2, 3, 4, Nicole Ochsenbein 5, 6, 7, Ladina Vonzun 5, 6, Luca Mazzone 8, 5, 9, 10, Maya Horst 8, 9, 10, Sonja Schauer 8, 9, 10, David Alexander Wille 11, 9, 10, Cornelia Hagmann 12, 10, Raimund Kottke 13, 10, Patrice Grehten 13, 10, Barbara Casanova 8, 5, 10, Nele Strübing 5, 6, Theres Moehrlen 8, 5, 10, Sasha Tharakan 8, 5, 10, Beth Padden 14, 9, 10, Dirk Bassler 15, 7, Roland Zimmermann # 5, 6, 7, Martin Meuli # 8, 5, 10, 7

    Over the past 10 years, over 150 fetal spina bifida surgeries were performed at the Zurich Center for Fetal Diagnosis and Therapy. This study looks at surrogates for success and failure of this approach.

    PMID: 33432393 DOI: 10.1007/s00383-020-04824-8

    Journal: Springer Pediatric Surgery International - published online: 12 January 2021

    DateEnglish: 20/01/2021

    1 Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    2 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    3 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    4 University of Zurich, Zurich, Switzerland. ueli.moehrlen@kispi.uzh.ch.

    5 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.

    6 Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland.

    7 University of Zurich, Zurich, Switzerland.

    8 Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.

    9 Zurich Center for Spina Bifida, University Children's Hospital Zurich, Zurich, Switzerland.

    10 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland.

    11 Division of Pediatric Neurology, University Children's Hospital Zurich, Zurich, Switzerland.

    12 Division of Intensive Care and Neonatology, University Children' Hospital Zurich, Zurich, Switzerland.

    13 Division of Diagnostic Imaging, MR-Center, University Children's Hospital Zurich, Zurich, Switzerland.

    14 Division of Pediatric Rehabilitation, University Children's Hospital Zurich, Zurich, Switzerland.

    15 Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.

    # Contributed equally.

    Urological Outcome after Fetal Spina Bifida Repair: Data from the Zurich Cohort

    Luca Mazzone 1, 2, 3, Alice Catherine Hölscher 4, 5, Ueli Moehrlen 6, 5, 7, Rita Gobet 4, 5, Martin Meuli 6, 5, 7, Maya Horst 4, 5

    Neurogenic lower urinary tract dysfunction (NLUTD) represents a severe burden for patients with open spina bifida (OSB). The effect of fetal OSB repair on the urological outcome remains unclear, as controversial data exist. The aim of this study was to further increment existing outcome data and to demonstrate that our earlier published positive preliminary results are not erratic.

    PMID: 32894833 PMCID: PMC7845448 DOI: 10.1159/000509392

    Journal: Karger Fetal Diagnosis and Therapie - published online: September 7, 2020

    DateEnglish: 01/12/2020

    1 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

    2 Division of Pediatric Urology, University Children's Hospital Zurich, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

    3 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland, luca.mazzone@kispi.uzh.ch.

    4 Division of Pediatric Urology, University Children's Hospital Zurich, Zurich, Switzerland.

    5 Children's Research Center, University Children's Hospital of Zurich, University of Zurich, Zurich, Switzerland.

    6 The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.

    7 Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

    Determination of Anatomical Levels in Spina Bifida Fetuses with Ultrasound and MRI

    Ladina Vonzun 1 2, Maike Katja Kahr 1, David Wille 3 4, Raimund Kottke 5 4, Ueli Moehrlen 6 2 4, Martin Meuli 6 2 4, Nicole Ochsenbein-Kölble 1 2, Franziska Kraehenmann 1 2, Roland Zimmermann 1 2, Luca Mazzone 6 2 4

    The goal of this study was to assess the accuracy of prenatal anatomical level determination by ultrasound (US) and magnetic resonance imaging (MRI) by analyzing the congruence with the "true" anatomical level identified by postnatal MRI.

    PMID: 33007788 DOI: 10.1055/a-1264-7785

    Journal: Thieme Ultraschall in Med - published online: 2. Oktober 2020

    DateEnglish: 02/10/2020

    1Department of Obstetrics, University Hospital of Zurich, Frauenklinikstrasse 10, 8006 Zurich, Switzerland.

    2The Zurich Center for Fetal Diagnosis and Therapy (www.swissfetus.ch), University of Zurich, Zurich, Switzerland.

    3Department of Pediatric Neurology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

    4Spina Bifida Center, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

    5Department of Diagnostic Imaging, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

    6Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.